@article { ISI:000391077000064,
	title = {Label-free femtomolar cancer biomarker detection in human serum using graphene-coated surface plasmon resonance chips},
	journal = {BIOSENSORS \& BIOELECTRONICS},
	volume = {89},
	number = {1, SI},
	year = {2017},
	month = {MAR 15},
	pages = {606-611},
	abstract = {Sensitive and selective detection of cancer biomarkers is vital for the successful diagnosis of early stage cancer and follow-up treatment. Surface Plasmon Resonance (SPR) in combination with different amplification strategies is one of the analytical approaches allowing the screening of protein biomarkers in serum. Here we describe the development of a point-of-care sensor for the detection of folic acid protein (FAP) using graphene-based SPR chips. The exceptional properties of CVD graphene were exploited to construct a highly sensitive and selective SPR chip for folate biomarker sensing in serum. The specific recognition of FAP is based on the interaction between folic acid receptors integrated through pi-stacking on the graphene coated SPR chip and the FAP analyte in serum. A simple post-adsorption of human serum:bovine serum albumin (HS:BSA) mixtures onto the folic acid modified sensor resulted in a highly anti-fouling interface, while keeping the sensing capabilities for folate biomarkers. This sensor allowed femtomolar (fM) detection of FAP, a detection limit well adapted and promising for quantitative clinical analysis. (C) 2016 Elsevier B.V. All rights reserved.},
	issn = {0956-5663},
	doi = {10.1016/j.bios.2016.01.076},
	author = {He, Lijie and Pagneux, Quentin and Larroulet, Iban and Serrano, Aritz Yanguas and Pesquera, Amaia and Zurutuza, Amaia and Mandler, Daniel and Boukherroub, Rabah and Szunerits, Sabine}
}
