@article {11234,
	title = {Label-free femtomolar cancer biomarker detection in human serum using graphene-coated surface plasmon resonance chips.},
	journal = {Biosens. Bioelectron.Biosensors \& Bioelectronics},
	volume = {89},
	number = {Part_1},
	year = {2017},
	note = {CAPLUS AN 2016:220193(Journal; Online Computer File)},
	month = {2017///},
	pages = {606 - 611},
	publisher = {Elsevier B.V.},
	abstract = {Sensitive and selective detection of cancer biomarkers is vital for the successful diagnosis of early stage cancer and follow-up treatment. Surface Plasmon Resonance (SPR) in combination with different amplification strategies is one of the anal. approaches allowing the screening of protein biomarkers in serum. Here we describe the development of a point-of-care sensor for the detection of folic acid protein (FAP) using graphene-based SPR chips. The exceptional properties of CVD graphene were exploited to construct a highly sensitive and selective SPR chip for folate biomarker sensing in serum. The specific recognition of FAP is based on the interaction between folic acid receptors integrated through π-stacking on the graphene coated SPR chip and the FAP analyte in serum. A simple post-adsorption of human serum:bovine serum albumin (HS:BSA) mixts. onto the folic acid modified sensor resulted in a highly anti-fouling interface, while keeping the sensing capabilities for folate biomarkers. This sensor allowed femtomolar (fM) detection of FAP, a detection limit well adapted and promising for quant. clin. anal. [on SciFinder(R)]},
	keywords = {serum cancer biomarker femtomolar graphene surface plasmon resonance chip},
	isbn = {0956-5663},
	author = {He, Lijie and Pagneux, Quentin and Larroulet, Iban and Serrano, Aritz Yanguas and Pesquera, Amaia and Zurutuza, Amaia and Mandler, Daniel and Boukherroub, Rabah and Szunerits, Sabine.}
}
