@article {7060,
	title = {Amplified detection of femtomolar DNA based on a one-to-few recognition reaction between DNA-Au conjugate and target DNA},
	journal = {NanoscaleNanoscale},
	volume = {6},
	number = {6},
	year = {2014},
	note = {MEDLINE AN 2014411439(Journal; Article; (JOURNAL ARTICLE); (RESEARCH SUPPORT, NON-U.S. GOV{\textquoteright}T))},
	month = {2014///},
	pages = {3110 - 5},
	abstract = {A sensitive electrochemical DNA biosensor based on the amplification of Au nanoparticles (AuNPs) has been developed. The AuNPs were modified with two types of signaling reporter DNAs, i.e. a methylene blue probe (MB-probe 2-SH) and T10 with a methylene blue signaling molecule (MB-T10-SH), forming DNA-AuNP conjugates. The MB-probe 2-SH is complementary to the target DNA, while MB-T10-SH is not. The presence of MB-T10-SH reduces the cross-reaction between target DNA and MB-probe 2-SH on the AuNPs, resulting in increased sensitivity of the biosensor. In our assay, the DNA sensor is fabricated by immobilizing a capture probe on the surface of the Au electrode, which then hybridizes with the corresponding target DNA, and further hybridizes with a DNA-Au conjugate. The signal of MB is measured by differential pulse voltammetry, while the DNA-Au conjugate enables the detection of target DNA in the linear range of 10(-13) to 10(-8) M with the detection limit as low as 50 fM.[on SciFinder (R)]},
	isbn = {2040-3372},
	author = {Wang, Zhijuan and Zhang, Juan and Zhu, Changfeng and Wu, Shixin and Mandler, Daniel and Marks, Robert S. and Zhang, Hua}
}
