@article {6916,
	title = {Electropolymerized Tricopolymer Based on N-Pyrrole Derivatives as a Primer Coating for Improving the Performance of a Drug-Eluting Stent.},
	journal = {ACS Appl. Mater. InterfacesACS Applied Materials \& Interfaces},
	volume = {1},
	number = {4},
	year = {2009},
	note = {CAPLUS AN 2009:300164(Journal)},
	month = {2009///},
	pages = {758 - 767},
	publisher = {American Chemical Society},
	abstract = {The coating of medical implants by polymeric films aims at increasing their biocompatibility as well as providing a durable matrix for the controlled release of a drug. In many cases, the coating is divided into a primer layer, which bridges between the medical implant and the drug-eluting matrix. The primer coating must be very carefully designed in order to provide optimal interactions with the surface of the medical implant and the outer layer. Here we present a simple and versatile approach for designing the primer layer based on electropolymn. of a carefully chosen blend of three different pyrrole derivs.: N-methylpyrrole (N-me), N-(2-carboxyethyl)pyrrole (PPA), and the Bu ester of N-(2-carboxyethyl)pyrrole (BuOPy). The compn. and phys. properties of the primer layer were studied in detail by at. force microscopy (AFM) and a nano scratch tester. The latter provides the in-depth anal. of the adhesion and viscoelasticity of the coating. AFM phase imaging reveals a uniform distribution of the three monomers forming rough morphol. This primer layer significantly improved the morphol., stability, and paclitaxel release profile of a paclitaxel-eluting matrix based on Me and lauryl methacrylates. [on SciFinder(R)]},
	keywords = {electropolymn tricopolymer pyrrole primer coating controlled release stent},
	isbn = {1944-8244},
	author = {Okner, Regina and Shaulov, Yulia and Tal, Noam and Favaro, Gregory and Domb, Abraham J. and Mandler, Daniel.}
}
