@article {6908,
	title = {Drug-eluting stent with improved durability and controllability properties, obtained via electrocoated adhesive promotion layer.},
	journal = {J. Biomed. Mater. Res., Part BJournal of Biomedical Materials Research, Part B: Applied Biomaterials},
	volume = {91B},
	number = {2},
	year = {2009},
	note = {CAPLUS AN 2009:1223301(Journal)},
	month = {2009///},
	pages = {819 - 830},
	publisher = {John Wiley \& Sons, Inc.},
	abstract = {Drug-eluting stents (DES) have become an accepted technol. in intravascular intervention. Manufg. methodologies of DES are based mainly on mech. processes, which tend to generate coatings that have poor stability properties; these were recently related as a potential hazard. A novel approach for significantly increasing the adhesion of polymer coatings onto DES is presented. The method is based on the electrochem. of diazonium salts. These substances are org. compds. with the characteristic structure of R-N X-, where R is an org. residue and X- is an anion. The objective of this article is to study the properties of a selected diazonium salt 4-(1-dodecyloxy)-phenyldiazonium tetrafluoroborate, referred as C12-phenyldiazonium. This material was found to be a superior adhesive promoter for polymeric coatings applied onto metallic stents. C12-phenyldiazonium was synthesized and electrocoated on metallic stents and plates. The multilayer films of C12-phenyldiazonium were further characterized through electrochem. (cyclic voltammetry, impedance spectroscopy), phys. (light and SEM, XPS, peeling tests), and chem. methodol. (high pressure liq. chromatog.). Further biocompatibility properties of the electrocoated basecoat were evaluated using in vitro and in vivo models. Synthesized C12-phenyldiazonium was successfully electrocoated onto metallic surfaces. Electrochem. tests demonstrated its efficient and controllable electrocoating. C12-phenyldiazonium was found to increase polymeric coating stability as was reflected by a std. adhesion test. Electrocoated metallic stents spray-coated with a second polymeric film showed improved durability following incubation in physiol. buffer. Furthermore, this improvement in durability exhibits stabilized drug release. In addn., biocompatibility evaluations have demonstrated basecoat{\textquoteright}s inert properties. {\textcopyright} 2009 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2009. [on SciFinder(R)]},
	keywords = {drug eluting stent adhesive promoter diazonium salt coating},
	isbn = {1552-4973},
	author = {Levy, Yair and Tal, Noam and Tzemach, Gilad and Weinberger, Judah and Domb, Abraham J. and Mandler, Daniel.}
}
