Detection of folic acid protein in human serum using reduced graphene oxide electrodes modified by folic-acid.

Citation:

Lijie He, Wang, Qian , Mandler, Daniel , Li, Musen , Boukherroub, Rabah , and Szunerits, Sabine. . 2016. “Detection Of Folic Acid Protein In Human Serum Using Reduced Graphene Oxide Electrodes Modified By Folic-Acid.”. Biosensors & Bioelectronics, 75, Pp. 389 - 395.

Abstract:

The detection of disease markers is considered an important step for early diagnosis of cancer. We design in this work a novel electrochem. sensing platform for the sensitive and selective detection of folic acid protein (FP). The platform is fabricated by electrophoretic deposition (EPD) of reduced graphene oxide (rGO) onto a gold electrode and post-functionalization of rGO with folic acid. Upon FP binding, a significant current decrease can be measured using differential pulse voltammetry (DPV). Using this scheme, a detection limit of 1 pM is achieved. Importantly, the method also allows the detection of FP in serum being thus an appealing approach for the sensitive detection of biomarkers in clin. samples. [on SciFinder(R)]