Abstract:

Novel biocompatible hybrid-material composed of iron-ion-crosslinked alginate with embedded protein mols. has been designed for the signal-triggered drug release. Electrochem. controlled oxidn. of Fe2+ ions in the presence of sol. natural alginate polymer and drug-mimicking protein (bovine serum albumin, BSA) results in the formation of an alginate-based thin-film crosslinked by Fe3+ ions at the electrode interface with the entrapped protein. The electrochem. generated composite thin-film was characterized by electrochem. and at. force microscopy (AFM). Preliminary expts. demonstrated that the electrochem. controlled deposition of the protein-contg. thin-film can be performed at microscale using scanning electrochem. microscopy (SECM) as the deposition tool producing polymer-patterned spots potentially contg. various entrapped drugs. Application of reductive potentials on the modified electrode produced Fe2+ cations which do not keep complexation with alginate, thus resulting in the electrochem. triggered thin-film dissoln. and the protein release. Different exptl. parameters, such as the film-deposition time, concns. of compds. and applied potentials, were varied in order to demonstrate that the electrodeposition and electrodissoln. of the alginate composite film can be tuned to the optimum performance. A statistical modeling technique was applied to find optimal conditions for the formation of the composite thin-film for the maximal encapsulation and release of the drug-mimicking protein at the lowest possible potential. [on SciFinder(R)]

Notes:

CAPLUS AN 2011:1670894(Journal; Online Computer File)