Electrochemically stimulated drug release from flexible electrodes coated electrophoretically with doxorubicin loaded reduced graphene oxide

Citation:

Lijie He, Sarkar, Sujoy , Barras, Alexandre , Boukherroub, Rabah , Szunerits, Sabine , and Mandler, Daniel . 2017. “Electrochemically Stimulated Drug Release From Flexible Electrodes Coated Electrophoretically With Doxorubicin Loaded Reduced Graphene Oxide”. Chemical Communications, 53, Pp. 4022-4025. doi:10.1039/c7cc00381a.

Abstract:

The electrochemically triggered release of doxorubicin (DOX) from flexible electrodes modified electrophoretically with reduced graphene oxide (rGO)-DOX is reported. The release is driven by a positive potential pulse that decreases the pH of the rGO-DOX surface locally, which is confirmed by scanning electrochemical microscopy (SECM) in situ. In vitro cell viability tests confirms that the delivery system meets therapeutic needs.