Electrocoating of stainless steel coronary stents for extended release of paclitaxel.

Citation:

R. Okner, Oron, M. , Tal, N. , Nyska, A. , Kumar, N. , Mandler, D, and Domb, A. J. 2008. “Electrocoating Of Stainless Steel Coronary Stents For Extended Release Of Paclitaxel.”. J. Biomed. Mater. Res., Part Ajournal Of Biomedical Materials Research, Part A, 88A, Pp. 427 - 436.

Abstract:

Nonbiodegradable polymer coating based on N-(2-carboxyethyl)pyrrole (PPA) and Bu ester of PPA (BuOPy) were successfully electrodeposited on a stainless steel stent surface using cyclic voltammetry. Chem. compn. of the coating was examd. by XPS. Polymer stability was examd. by immersing the coated stent into 1:1 soln. of fetal calf serum:seline soln. up to 1 yr and implantation s.c. in mouse for 1 wk. Morphol. changes were then recorded by SEM. Paclitaxel loading was carried out by immersion into drug soln. and its release was detected by HPLC. The results show that thin (single micrometers), uniform coating with various morphol. and hydrophobicity can be created by electrochem. deposition. The polymer did not show significant histopathol. or morphol. changes in vitro and in vivo. The surface properties allow loading appropriate amts. of paclitaxel and release it slowly up to a month. [on SciFinder(R)]