Publications

2012
Zhiyuan Jin, Gueven, Guray , Bocharova, Vera , Halamek, Jan , Tokarev, Ihor , Minko, Sergiy , Melman, Artem , Mandler, Daniel , and Katz, Evgeny . 2012. Electrochemically Controlled Drug-Mimicking Protein Release From Iron-Alginate Thin-Films Associated With An Electrode. Acs Applied Materials & Interfaces, 4, Pp. 466-475. doi:10.1021/am201578m.
Zhiyuan Jin, Guven, Guray , Bocharova, Vera , Halamek, Jan , Tokarev, Ihor , Minko, Sergiy , Melman, Artem , Mandler, Daniel , and Katz, Evgeny . 2012. Electrochemically Controlled Drug-Mimicking Protein Release From Iron-Alginate Thin-Films Associated With An Electrode. Acs Appl Mater Interfacesacs Applied Materials & Interfaces, 4, Pp. 466 - 75. Abstract
Novel biocompatible hybrid-material composed of iron-ion-cross-linked alginate with embedded protein molecules has been designed for the signal-triggered drug release. Electrochemically controlled oxidation of Fe(2+) ions in the presence of soluble natural alginate polymer and drug-mimicking protein (bovine serum albumin, BSA) results in the formation of an alginate-based thin-film cross-linked by Fe(3+) ions at the electrode interface with the entrapped protein. The electrochemically generated composite thin-film was characterized by electrochemistry and atomic force microscopy (AFM). Preliminary experiments demonstrated that the electrochemically controlled deposition of the protein-containing thin-film can be performed at microscale using scanning electrochemical microscopy (SECM) as the deposition tool producing polymer-patterned spots potentially containing various entrapped drugs. Application of reductive potentials on the modified electrode produced Fe(2+) cations which do not keep complexation with alginate, thus resulting in the electrochemically triggered thin-film dissolution and the protein release. Different experimental parameters, such as the film-deposition time, concentrations of compounds and applied potentials, were varied in order to demonstrate that the electrodepositon and electrodissolution of the alginate composite film can be tuned to the optimum performance. A statistical modeling technique was applied to find optimal conditions for the formation of the composite thin-film for the maximal encapsulation and release of the drug-mimicking protein at the lowest possible potential.[on SciFinder (R)]
Zhiyuan Jin, Guven, Guray , Bocharova, Vera , Halamek, Jan , Tokarev, Ihor , Minko, Sergiy , Melman, Artem , Mandler, Daniel , and Katz, Evgeny. . 2012. Electrochemically Controlled Drug-Mimicking Protein Release From Iron-Alginate Thin-Films Associated With An Electrode.. Acs Appl. Mater. Interfacesacs Applied Materials & Interfaces, 4, Pp. 466 - 475. Abstract
Novel biocompatible hybrid-material composed of iron-ion-crosslinked alginate with embedded protein mols. has been designed for the signal-triggered drug release. Electrochem. controlled oxidn. of Fe2+ ions in the presence of sol. natural alginate polymer and drug-mimicking protein (bovine serum albumin, BSA) results in the formation of an alginate-based thin-film crosslinked by Fe3+ ions at the electrode interface with the entrapped protein. The electrochem. generated composite thin-film was characterized by electrochem. and at. force microscopy (AFM). Preliminary expts. demonstrated that the electrochem. controlled deposition of the protein-contg. thin-film can be performed at microscale using scanning electrochem. microscopy (SECM) as the deposition tool producing polymer-patterned spots potentially contg. various entrapped drugs. Application of reductive potentials on the modified electrode produced Fe2+ cations which do not keep complexation with alginate, thus resulting in the electrochem. triggered thin-film dissoln. and the protein release. Different exptl. parameters, such as the film-deposition time, concns. of compds. and applied potentials, were varied in order to demonstrate that the electrodeposition and electrodissoln. of the alginate composite film can be tuned to the optimum performance. A statistical modeling technique was applied to find optimal conditions for the formation of the composite thin-film for the maximal encapsulation and release of the drug-mimicking protein at the lowest possible potential. [on SciFinder(R)]
Zhijuan Wang, Zhang, Juan , Yin, Zongyou , Wu, Shixin , Mandler, Daniel , and Zhang, Hua. . 2012. Fabrication Of Nanoelectrode Ensembles By Electrodeposition Of Au Nanoparticles On Single-Layer Graphene Oxide Sheets.. Nanoscalenanoscale, 4, Pp. 2728 - 2733. Abstract
Nanoelectrode ensembles (NEEs) have been fabricated by the electrodeposition of Au nanoparticles (AuNPs) on single-layer graphene oxide (GO) sheets coated on a glassy carbon electrode (GCE). The fabricated NEEs show a typical sigmoidal shaped voltammetric profile, arising from the low coverage d. of AuNPs on GCE and large distance among them, which can be easily controlled by varying the electrodeposition time. As a proof of concept, after the probe HS-DNA is immobilized on the NEEs through the Au-S bonding, the target DNA was detected with the methylene blue intercalator. The authors’ results show that the target DNA can be detected as low as 100 fM, i.e. 0.5 amol DNA in 5 μL soln. [on SciFinder(R)]
Zhijuan Wang, Zhang, Juan , Yin, Zongyou , Wu, Shixin , Mandler, Daniel , and Zhang, Hua . 2012. Fabrication Of Nanoelectrode Ensembles By Electrodepositon Of Au Nanoparticles On Single-Layer Graphene Oxide Sheets. Nanoscale, 4, Pp. 2728-2733. doi:10.1039/c2nr30142c.
Zhijuan Wang, Zhang, Juan , Yin, Zongyou , Wu, Shixin , Mandler, Daniel , and Zhang, Hua . 2012. Fabrication Of Nanoelectrode Ensembles By Electrodepositon Of Au Nanoparticles On Single-Layer Graphene Oxide Sheets. Nanoscalenanoscale, 4, Pp. 2728 - 33. Abstract
Nanoelectrode ensembles (NEEs) have been fabricated by the electrodeposition of Au nanoparticles (AuNPs) on single-layer graphene oxide (GO) sheets coated on a glassy carbon electrode (GCE). The fabricated NEEs show a typical sigmoidal shaped voltammetric profile, arising from the low coverage density of AuNPs on GCE and large distance among them, which can be easily controlled by varying the electrodeposition time. As a proof of concept, after the probe HS-DNA is immobilized on the NEEs through the Au-S bonding, the target DNA is detected with the methylene blue intercalator. Our results show that the target DNA can be detected as low as 100 fM, i.e. 0.5 amol DNA in 5 μL solution.[on SciFinder (R)]
Daphna Mandler, Mamlok-Naaman, Rachel , Blonder, Ron , Yayon, Malka , and Hofstein, Avi . 2012. High-School Chemistry Teaching Through Environmentally Oriented Curricula. Chemistry Education Research And Practice, 13, Pp. 80-92. doi:10.1039/c1rp90071d.
Nimer Jaber, Lesniewski, Adam , Gabizon, Hadar , Shenawi, Sanaa , Mandler, Daniel , and Almog, Joseph . 2012. Visualization Of Latent Fingermarks By Nanotechnology: Reversed Development On Paper–A Remedy To The Variation In Sweat Composition. Angew Chem Int Ed Englangewandte Chemie (International Ed. In English), 51, Pp. 12224 - 7.
Nimer Jaber, Lesniewski, Adam , Gabizon, Hadar , Shenawi, Sanaa , Mandler, Daniel , and Almog, Joseph . 2012. Visualization Of Latent Fingermarks By Nanotechnology: Reversed Development On Papera Remedy To The Variation In Sweat Composition. Angewandte Chemie-International Edition, 51, Pp. 12224-12227. doi:10.1002/anie.201205259.
Nimer Jaber, Lesniewski, Adam , Gabizon, Hadar , Shenawi, Sanaa , Mandler, Daniel , and Almog, Joseph. . 2012. Visualization Of Latent Fingermarks By Nanotechnology: Reversed Development On Paper-A Remedy To The Variation In Sweat Composition.. Angew. Chem., Int. Ed.angewandte Chemie, International Edition, 51, Pp. 12224 - 12227. Abstract
In this work, "neg." fingermarks have been developed on paper, even after soaking in water, by the application of a new bifunctional reagent attached to gold nanoparticles, and then a silver phys. developer. The bifunctional reagent is composed of an active head, i.e., a polar group with high affinity to cellulose, attached by a long chain to an active tail contg. a sulfur group, which can stabilize gold nanoparticles. Through the active head, the gold nanoparticles, which are stabilized by the active tail, adhere preferentially to the paper cellulose rather than to the fingerprint material, to which they conventionally bind. Consequently, silver developer, which normally develops sebaceous fingermarks by pptg. dark silver on the sebaceous material, ppt. preferentially on the gold-coated areas giving rise to the appearance of uncolored ridge detail on a dark background. In this competing process, the paper itself serves as the substrate, whereas the fingermarks serve as a mask. This process may increase the overall yield of developed fingermarks as it bypasses the issue of the remarkable differences in sweat compn. between individual persons. [on SciFinder(R)]
2011
Tamar Danieli, Colleran, John , and Mandler, Daniel. . 2011. Deposition Of Au And Ag Nanoparticles On Pedot.. Phys. Chem. Chem. Phys.physical Chemistry Chemical Physics, 13, Pp. 20345 - 20353. Abstract
The deposition of Au and Ag, locally and from bulk soln., on poly(3,4-ethylenedioxythiophene) (PEDOT) was studied. Specifically, PEDOT was electrochem. polymd. onto a glassy carbon (GC) electrode and used for bulk deposition of Au and Ag from their resp. ions dissolved in the soln. as well as for the local deposition of these metals using scanning electrochem. microscopy (SECM). These two sets of expts. were utilized to investigate the difference between Au and Ag electrochem. deposition on PEDOT. In particular, SECM expts., which were conducted by the controlled anodic dissoln. of Au and Ag microelectrodes close to GC/PEDOT, probed the effect of different PEDOT oxidn. states on local deposition. The current-time transients recorded during the deposition, combined with SEM and energy-dispersive x-ray anal. provided insight into the redn. processes. AuCl4- and Ag+ ions were electrochem. reduced at a potential equal to and more neg. than the ions redox potentials (0.4 and 0.2 V, resp.) and more pos. than -0.7 V, where the PEDOT starts transforming into the reduced, i.e. insulating, state. We found that the electroredn. of Ag+ ions was diffusion-controlled and the PEDOT film served as a simple conductor. The redn. of AuCl4- ions was enhanced on GC/PEDOT as compared with bare GC, indicating that PEDOT catalyzes the redn. of AuCl4- to Au. [on SciFinder(R)]
Tamar Danieli, Colleran, John , and Mandler, Daniel . 2011. Deposition Of Au And Ag Nanoparticles On Pedot. Physical Chemistry Chemical Physics, 13, Pp. 20345-20353. doi:10.1039/c1cp22093d.
Tamar Danieli, Colleran, John , and Mandler, Daniel . 2011. Deposition Of Au And Ag Nanoparticles On Pedot. Phys Chem Chem Physphysical Chemistry Chemical Physics : Pccp, 13, Pp. 20345 - 53. Abstract
The deposition of Au and Ag, locally and from bulk solution, on poly(3,4-ethylenedioxythiophene) (PEDOT) was studied. Specifically, PEDOT was electrochemically polymerized onto a glassy carbon (GC) electrode and used for bulk deposition of Au and Ag from their respective ions dissolved in the solution as well as for the local deposition of these metals using scanning electrochemical microscopy (SECM). These two sets of experiments were utilized to investigate the difference between Au and Ag electrochemical deposition on PEDOT. In particular, SECM experiments, which were conducted by the controlled anodic dissolution of Au and Ag microelectrodes close to GC/PEDOT, probed the effect of different PEDOT oxidation states on local deposition. The current-time transients recorded during the deposition, combined with scanning electron microscopy and EDX analysis provided insight into the reduction processes. AuCl(4)(-) and Ag(+) ions were electrochemically reduced at a potential equal to and more negative than the ions redox potentials (0.4 and 0.2 V, respectively) and more positive than -0.7 V, where the PEDOT starts transforming into the reduced, i.e. insulating, state. We found that the electroreduction of Ag(+) ions was diffusion-controlled and the PEDOT film served as a simple conductor. On the other hand, the reduction of AuCl(4)(-) ions was enhanced on GC/PEDOT as compared with bare GC, indicating that PEDOT catalyzes the reduction of AuCl(4)(-) to Au.[on SciFinder (R)]
Tomer Noyhouzer and Mandler, Daniel . 2011. Determination Of Low Levels Of Cadmium Ions By The Under Potential Deposition On A Self-Assembled Monolayer On Gold Electrode. Anal Chim Actaanalytica Chimica Acta, 684, Pp. 1 - 7. Abstract
The electrochemical determination of low levels of Cd using a self-assembled monolayer (SAM) modified Au electrode is reported. Determination was based on the stripping of Cd, which was deposited by under potential deposition (UPD). A series of short alkanethiol SAMs bearing different end groups, i.e., sulfonate, carboxylate and ammonium, were examined. Lowest level of detection (ca. 50 ngL(-1)) was achieved with a 3-mercaptopropionic acid (MPA) monolayer using subtractive anodic square wave voltammetry (SASV). Additional surface methods, namely, reductive desorption and X-ray photoelectron spectroscopy, were applied to determine the interfacial structure of the electrodeposited Cd on the modified electrodes. We conclude that the deposited Cd forms a monoatomic layer, which bridges between the gold surface and the alkanethiol monolayer associating with both the gold and the sulfur atoms.[on SciFinder (R)]
Tomer Noyhouzer and Mandler, Daniel. . 2011. Determination Of Low Levels Of Cadmium Ions By The Under Potential Deposition On A Self-Assembled Monolayer On Gold Electrode.. Anal. Chim. Actaanalytica Chimica Acta, 684, Pp. 1 - 7. Abstract
The electrochem. detn. of low levels of Cd using a self-assembled monolayer (SAM) modified Au electrode is reported. Detn. was based on the stripping of Cd, which was deposited by under potential deposition (UPD). Short alkanethiol SAMs bearing different end groups, i.e., sulfonate, carboxylate and ammonium, were examd. Lowest level of detection (\~50 ng/L-1) was achieved with a 3-mercaptopropionic acid (MPA) monolayer using subtractive anodic square wave voltammetry (SASV). Addnl. surface methods, namely, reductive desorption and XPS, were applied to det. the interfacial structure of the electrodeposited Cd on the modified electrodes. The deposited Cd forms a monoat. layer, which bridges between the gold surface and the alkanethiol monolayer assocg. with both the gold and the sulfur atoms. [on SciFinder(R)]
Tomer Noyhouzer and Mandler, Daniel . 2011. Determination Of Low Levels Of Cadmium Ions By The Under Potential Deposition On A Self-Assembled Monolayer On Gold Electrode. Analytica Chimica Acta, 684, Pp. 1-7. doi:10.1016/j.aca.2010.10.021.
Regina Guslitzer-Okner and Mandler, Daniel . 2011. Electrochemical Coating Of Medical Implants. In Applications Of Electrochemistry And Nanotechnology In Biology And Medicine I, Pp. 291-340. doi:10.1007/978-1-4614-0347-0_4.
Regina Guslitzer-Okner and Mandler, Daniel. . 2011. Electrochemical Coating Of Medical Implants.. Mod. Aspects Electrochem.modern Aspects Of Electrochemistry, 52, Pp. 291 - 342. Abstract
A review on the various studies of electroplating of medical devices, such as implants, including the different methods of electrochem. deposition and the various substrates electrochem. coated. [on SciFinder(R)]
Efrat Gdor and Mandler, Daniel. . 2011. Electrochemically Assisted Deposition Of Biodegradable Polymer Nanoparticles/Sol-Gel Thin Films.. J. Mater. Chem.journal Of Materials Chemistry, 21, Pp. 12145 - 12150. Abstract
Biodegradable nanoparticles represent a promising platform for controlled release and other applications in medicine. To alter the interface of the medical device with the living tissue successfully, a thin coating needs to be applied onto the surface. The traits and functionality of the coating depends on its components, which in the presented work are sol-gel and biodegradable nanoparticles (NPs) deposited onto the substrate using the electrochem. sol-gel method. Aspects affecting the deposition process were investigated such as the applied potential and its duration. The properties of the deposits with emphasis on the biodegradable NPs within the deposited films were characterized and studied. Another element examd. was the loading ability of the NPs. A fluorescent org. mol. was incorporated in the biodegradable NPs as a drug model, to demonstrate loading capability. [on SciFinder(R)]
Efrat Gdor and Mandler, Daniel . 2011. Electrochemically Assisted Deposition Of Biodegradable Polymer Nanoparticles/Sol-Gel Thin Films. Journal Of Materials Chemistry, 21, Pp. 12145-12150. doi:10.1039/c1jm11262g.