Electropolymerized Tricopolymer Based on N-Pyrrole Derivatives as a Primer Coating for Improving the Performance of a Drug-Eluting Stent.

Citation:

Regina Okner, Shaulov, Yulia , Tal, Noam , Favaro, Gregory , Domb, Abraham J. , and Mandler, Daniel. . 2009. “Electropolymerized Tricopolymer Based On N-Pyrrole Derivatives As A Primer Coating For Improving The Performance Of A Drug-Eluting Stent.”. Acs Appl. Mater. Interfacesacs Applied Materials & Interfaces, 1, Pp. 758 - 767.

Abstract:

The coating of medical implants by polymeric films aims at increasing their biocompatibility as well as providing a durable matrix for the controlled release of a drug. In many cases, the coating is divided into a primer layer, which bridges between the medical implant and the drug-eluting matrix. The primer coating must be very carefully designed in order to provide optimal interactions with the surface of the medical implant and the outer layer. Here we present a simple and versatile approach for designing the primer layer based on electropolymn. of a carefully chosen blend of three different pyrrole derivs.: N-methylpyrrole (N-me), N-(2-carboxyethyl)pyrrole (PPA), and the Bu ester of N-(2-carboxyethyl)pyrrole (BuOPy). The compn. and phys. properties of the primer layer were studied in detail by at. force microscopy (AFM) and a nano scratch tester. The latter provides the in-depth anal. of the adhesion and viscoelasticity of the coating. AFM phase imaging reveals a uniform distribution of the three monomers forming rough morphol. This primer layer significantly improved the morphol., stability, and paclitaxel release profile of a paclitaxel-eluting matrix based on Me and lauryl methacrylates. [on SciFinder(R)]